Phenotype Help

TRX1 / YLR043C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

21 entries for 11 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chromosome/plasmid maintenance: decreased
heterozygous diploidnull
Allele: trx1-Δ
OtherDetails: >2-fold increase in the rate of chromosome loss, indicative of chromosome instability (CIN)
Strome ED, et al. (2008) PMID:18245329
chronological lifespan: decreased
systematic mutation setnull
Allele: trx1-Δ
S288CLaschober GT, et al. (2010) PMID:20883526
colony sectoring: increased
heterozygous diploid, systematic mutation setnull
Allele: trx1-Δ
S288CAssay: quantitative chromosome transmission fidelity (qCTF) assay
Details: >1.5 fold increase in mini-chromosome loss relative to wt, indicative of chromosome instability (CIN)
Zhu J, et al. (2015) PMID:25823586
competitive fitness: increased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: trx1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 1.005
Breslow DK, et al. (2008) PMID:18622397
metal resistance: decreased
classical genetics null
Allele: trx1-Δ
S288C80 μM cadmium(2+)Wang J, et al. (2021) PMID:33770215
metal resistance: decreased
classical genetics null
Allele: trx1-Δ
S288C80 μM chromium(3+)Wang J, et al. (2021) PMID:33770215
oxidative stress resistance: decreased
heterozygous diploid, systematic mutation setnull
Allele: trx1-Δ
S288C3 mM hydrogen peroxideOkada N, et al. (2014) PMID:24410772
protein/peptide modification: increased
Reporter: Yvc1p
classical geneticsnull
Allele: trx1-Δ
S288CDetails: increased glutathionylation of Yvc1p
Chandel A, et al. (2016) PMID:27708136
resistance to chemicals: decreased
competitive growth

fitness profiling of the non-essential deletion collection after 18 generations

null
Allele: trx1-Δ
S288C20 ug/ml cordycepinDetails: sensitivity increased two-fold or greater
Holbein S, et al. (2009) PMID:19324962
resistance to chemicals: decreased
heterozygous diploidnull
Allele: trx1-Δ
Other10 ug/ml benomylStrome ED, et al. (2008) PMID:18245329
Showing 1 to 10 of 21 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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