Phenotype Help

SSK1 / YLR006C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

77 entries for 30 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
actin cytoskeleton morphology: abnormal
classical geneticsnull
Allele: ssk1-Δ
S288CMedia: low pH, pH 3.0
Details: actin depolarization delayed in response to low pH
Motizuki M and Xu Z (2009) PMID:19633059
cell size: increased
classical geneticsoverexpressionS288CDetails: see Table S7 for more details
Sopko R, et al. (2006) PMID:16455487
cellular morphology: abnormal
classical geneticsoverexpressionS288CDetails: see Table S7 for more details
Sopko R, et al. (2006) PMID:16455487
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: ssk1-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
chemical compound excretion: increased
homozygous diploid, systematic mutation set

quantification of extracellular glutathione at stationary phase

null
Allele: ssk1-Δ
S288C glutathioneTreatment: SD medium
Details: Fold elevation of glutathione excretion: 6
Perrone GG, et al. (2005) PMID:15509654
chromosome/plasmid maintenance: decreased
heterozygous diploidnull
Allele: ssk1-Δ
OtherDetails: >2-fold increase in the rate of chromosome loss, indicative of chromosome instability (CIN)
Strome ED, et al. (2008) PMID:18245329
colony sectoring: increased
heterozygous diploid, systematic mutation setnull
Allele: ssk1-Δ
S288CAssay: quantitative chromosome transmission fidelity (qCTF) assay
Details: >1.5 fold increase in mini-chromosome loss relative to wt, indicative of chromosome instability (CIN)
Zhu J, et al. (2015) PMID:25823586
competitive fitness: decreased
systematic mutation set

fitness profiling after 15 generations

null
Allele: ssk1-Δ
S288CMedia: alkaline conditions, pH 8
Giaever G, et al. (2002) PMID:12140549
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: ssk1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.991
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: ssk1-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
Showing 1 to 10 of 77 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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