Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
12 entries for 9 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| autophagy: decreased | classical genetics | null Allele: iml1-Δ | Other | Media: nitrogen starvation Details: autophagic induction and flux are decreased; monitored by the maturation and localization of autophagy marker GFP-Atg8 | Algret R, et al. (2014) PMID:25073740 | |
| autophagy: decreased | classical genetics | null Allele: iml1-Δ | S288C | Media: nitrogen starvation Details: defective nitrogen-starvation-induced autophagy, assayed using an ALP-based assay to assess delivery of Pho8Delta60 to the vacuole | Kira S, et al. (2014) PMID:25046117 | |
| filamentous growth: increased | systematic mutation set | null Allele: iml1-Δ | Sigma1278b | Details: greatly increased | Jin R, et al. (2008) PMID:17989363 | |
| growth in exponential phase: decreased rate | classical genetics | null Allele: iml1-Δ | CEN.PK | Temperature: elevated temperature, 42 °C Details: significant reduction in growth rate at high temperature relative to wt | Sornlek W, et al. (2024) PMID:39230763 | |
| oxidative stress resistance: decreased | classical genetics | null Allele: iml1-Δ | S288C | 0.75 mM hydrogen peroxide | Details: increased sensitivity to H2O2-induced oxidative stress, similar to the GTP-restricted allele of GTPase, gtr1-Q65L | Sekiguchi T, et al. (2022) PMID:35158208 |
| protein/peptide accumulation: increased Reporter: Npr3p-GFP | classical genetics | null Allele: iml1-Δ | Other | sirolimus | Details: Npr3p is stabilized in cells treated with rapamycin | Algret R, et al. (2014) PMID:25073740 |
| protein/peptide distribution: abnormal Reporter: Tor1p-GFP | classical genetics | null Allele: iml1-Δ | Other | Media: nitrogen starvation Details: Tor1p becomes dispersed in cytoplasmic foci after 20 hrs of nitrogen starvation, rather than remain in the vacuolar membrane | Algret R, et al. (2014) PMID:25073740 | |
| protein/peptide modification: decreased Reporter: Sch9p-Ha5 | classical genetics | overexpression | S288C | Details: decreased phosphorylation of TORC1 target Sch9p at residue T737, indicative of attenuated TORC1 activity | Panchaud N, et al. (2013) PMID:23716719 | |
| protein/peptide modification: increased Reporter: Sch9p-Ha5 | classical genetics | null Allele: iml1-Δ | S288C | Details: elevated phosphorylation of TORC1 target Sch9p at residue T737, indicative of increased TORC1 activity | Panchaud N, et al. (2013) PMID:23716719 | |
| protein/peptide modification: increased Reporter: Sch9p-Ha5 | classical genetics | null Allele: iml1-Δ | S288C | Media: leucine starvation Details: increased phosphorylation of TORC1 target Sch9p at residue T737, indicative of decreased sensitivity of TORC1 to leucine starvation | Panchaud N, et al. (2013) PMID:23716719 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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