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SET2 / YJL168C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
EZL1 , KMT3 10
Protein Product
histone methyltransferase SET2
Feature Type
ORF , Verified
Description
Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia 2 3 4 5 7 8 9
EC Number
2.1.1.359

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