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TPK1 / YJL164C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
SRA3 40 , PKA1
Protein Product
cAMP-dependent protein kinase catalytic subunit TPK1
Feature Type
ORF , Verified
Description
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication 2 3 4 6 7 8
Paralog
TPK3 6
EC Number
2.7.11.11

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