PHO86 / YJL117W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

PHO86/YJL117W is a non-essential gene; null mutants are viable, quick-growing, and associated with several phenotypes that significantly impact cellular functions and overall fitness. In null mutants, resistance to alkaline pH is decreased, indicating a compromised ability to thrive in basic environments. These mutants also exhibit diminished competitive fitness and a reduced growth rate during the exponential phase, which can hinder their ability to proliferate effectively. Additionally, resistance to hyperosmotic stress is decreased, although these mutants show increased resistance to killer toxins, suggesting a complex response to environmental challenges. The morphology of lipid particles is abnormal, and oxidative stress resistance is also reduced, highlighting their vulnerability to oxidative damage. Sporulation is decreased, indicating potential reproductive challenges. Vacuolar morphology is abnormal, which may disrupt cellular storage and waste management. Overexpression slows growth, suggesting that excessive levels of the gene product may negatively impact cellular health and growth dynamics.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources