Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
21 entries for 17 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| cell cycle progression: abnormal | systematic mutation set | overexpression | S288C | Details: accumulation of cells with a 2C DNA content and an increased percentage of large-budded cells indicative of a G2 or M phase delay or arrest | Niu W, et al. (2008) PMID:18617996 | |
| chromosome/plasmid maintenance: decreased | heterozygous diploid | null Allele: ime2-Δ | Other | Details: >2-fold increase in the rate of chromosome loss, indicative of chromosome instability (CIN) | Strome ED, et al. (2008) PMID:18245329 | |
| chronological lifespan: increased | systematic mutation set | null Allele: ime2-Δ | S288C | Campos SE, et al. (2018) PMID:29575540 | ||
| colony sectoring: increased | homozygous diploid | overexpression | Other | Details: elevated sectoring due to loss of a supernumerary chromosome fragment, an indicator of chromosome instability | Frumkin JP, et al. (2016) PMID:27530428 | |
| colony sectoring: increased | heterozygous diploid, systematic mutation set | null Allele: ime2-Δ | S288C | Assay: quantitative chromosome transmission fidelity (qCTF) assay Details: >1.5 fold increase in mini-chromosome loss relative to wt, indicative of chromosome instability (CIN) | Zhu J, et al. (2015) PMID:25823586 | |
| competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: ime2-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.987 | Breslow DK, et al. (2008) PMID:18622397 | |
| competitive fitness: decreased | competitive growth | overexpression | S288C | Details: decreased abundance within the barFLEX overexpression collection arrayed after 20 generations of pooled growth | Douglas AC, et al. (2012) PMID:23050238 | |
| haploproficient | heterozygous diploid, competitive growth | null Allele: ime2-Δ | S288C | Treatment: conditions that mimic Phase II of a batch fermentation, equivalent to ~22 hours after inoculation of a batch fermentation | Novo M, et al. (2013) PMID:24040173 | |
| invasive growth: increased | homozygous diploid, systematic mutation set | overexpression | Sigma1278b | Media: nitrogen-sufficient medium Details: agar invasion score: 0.99; enhanced pseudohyphal growth, based on elevated invasiveness | Shively CA, et al. (2013) PMID:23410832 | |
| liquid culture appearance: abnormal | systematic mutation set | null Allele: ime2-Δ | S288C | Details: Creeping phenotype: When cells of opposite mating type are mixed in liquid media, they 'creep' up the culture vessel sides | Arras SDM, et al. (2022) PMID:35298616 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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