Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
25 entries for 15 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| autophagy: increased | classical genetics | conditional Allele: net1-1 | W303 | Temperature: elevated temperature, 37 °C Details: autophagy monitored by processing of GFP-Atg8p | Kondo A, et al. (2018) PMID:29694832 | |
| chemical compound excretion: increased | systematic mutation set Dox titratable strains: Tet-regulated promoter that is shut off by the addition of doxycycline | repressible | S288C | inositol | Details: Opi- phenotype; overproduction and excretion of inositol in the absence of inositol and choline | Salas-Santiago B and Lopes JM (2014) PMID:24558266 |
| chromosome segregation: decreased | homozygous diploid | reduction of function Allele: net1-6Cdk T62A, S166A, T212A, S252A, T297A, T304A; all Cdk-consensus sites within amino acids 1-341 mutated | W303 | Phase: meiosis I Details: inhibition of rDNA segregation during meiosis I; fail to disjoin their rDNA while traversing meiosis I and remains in a single mass into meiotic metaphase II | Yellman CM (2023) PMID:37530060 | |
| chromosome segregation: delayed | classical genetics | reduction of function Allele: net1-6Cdk T62A, S166A, T212A, S252A, T297A, T304A; all Cdk consensus sites within amino acids 1-341 mutated | W303 | Details: 10 minute delay in the segregation of ribosomal DNA (rDNA) during mitosis | Azzam R, et al. (2004) PMID:15273393 | |
| competitive fitness: decreased | competitive growth fitness profiling of essential genes using hypomorphic DAmP alleles | reduction of function | S288C | Media: minimal medium Details: Relative fitness score: 0.998 | Breslow DK, et al. (2008) PMID:18622397 | |
| growth in exponential phase: decreased rate | classical genetics | unspecified Allele: net1-T62A,S385A T62A, S385A; Hog1p phosphorylation sites mutated | W303 | 1 M sodium chloride | Treatment: metaphase-block release Details: osmosensitive; decreased recovery and osmoadaptation in metaphase-synchronized cells relative to wt | Tognetti S, et al. (2020) PMID:32265285 |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: net1-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0063 | Pir P, et al. (2012) PMID:22244311 | |
| haploinsufficient | heterozygous diploid, systematic mutation set | null Allele: net1-Δ | S288C | Ohnuki S and Ohya Y (2018) PMID:29768403 | ||
| inviable | systematic mutation set | null Allele: net1-Δ | S288C | Giaever G, et al. (2002) PMID:12140549 | ||
| protein/peptide accumulation: increased Reporter: Mob1 | classical genetics | activation | W303 | Details: increased localization to nucleus prior to anaphase | Zhou X, et al. (2021) PMID:33481703 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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