Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
24 entries for 20 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| bud morphology: abnormal | large-scale survey | conditional | Other | Temperature: elevated temperature, 37 °C | Kanemaki M, et al. (2003) PMID:12768207 | |
| cell cycle progression in S phase: abnormal | large-scale survey | repressible | S288C | Details: accumulation of cells with a DNA content between 1C and 2C indicative of an S phase delay | Yu L, et al. (2006) PMID:16943325 | |
| cell cycle progression through the G1/S phase transition: delayed | heterozygous diploid | null Allele: psf2-Δ | S288C | Details: increased accumulation of cells in the G1 phase of the cell cycle, indicative of a slight delay in the G1/S phase transition | Stępień K, et al. (2024) PMID:37907194 | |
| cell cycle progression: abnormal | large-scale survey | conditional | Other | Temperature: elevated temperature, 37 °C | Kanemaki M, et al. (2003) PMID:12768207 | |
| chemical compound excretion: increased | systematic mutation set Dox titratable strains: Tet-regulated promoter that is shut off by the addition of doxycycline | repressible | S288C | inositol | Details: Opi- phenotype; overproduction and excretion of inositol in the absence of inositol and choline | Salas-Santiago B and Lopes JM (2014) PMID:24558266 |
| chromosome/plasmid maintenance: abnormal | classical genetics | conditional Allele: psf2-ts | S288C | Assay: a-like faker (ALF) assay Temperature: elevated temperature, 30 °C - 37 °C Details: indicative of chromosome instability (CIN) | Ben-Aroya S, et al. (2008) PMID:18439903 | |
| chromosome/plasmid maintenance: decreased | large-scale survey | repressible | S288C | 10 ug/ml doxycycline | Details: Tet-regulated essential ORF strain collection (doxycycline represses expression)|; increased chromosome rearrangements and chromosome loss, as measured in an illegitimate mating assay; increased spontaneous DNA damage as measured by an increase of Ddc2 foci relative to wild-type | Cheng E, et al. (2012) PMID:22673806 |
| chronological lifespan: abnormal | heterozygous diploid | null Allele: psf2-Δ | S288C | Details: delayed chronological aging; exhibits delayed senescence during the initial 14 days; incapable of forming colonies beyond 21 days while wt cells remain viable; increased cell size from the onset with declining viability and reduction in ploidy over time | Stępień K, et al. (2024) PMID:37907194 | |
| colony sectoring: increased | classical genetics | conditional Allele: psf2-ts | S288C | Assay: chromosome transmission fidelity (CTF) assay Temperature: elevated temperature, 30 °C - 37 °C Details: indicative of chromosome instability (CIN); metascore intermediate | Ben-Aroya S, et al. (2008) PMID:18439903 | |
| competitive fitness: increased | competitive growth fitness profiling of essential genes using hypomorphic DAmP alleles | reduction of function | S288C | Media: minimal medium Details: Relative fitness score: 1.003 | Breslow DK, et al. (2008) PMID:18622397 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome