ZUO1 / YGR285C Homology
- Standard Name
- ZUO1 1
- Systematic Name
- YGR285C
- SGD ID
- SGD:S000003517
- Feature Type
- ORF , Verified
- Description
- Ribosome-associated co-chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains with Ssz1p and Ssb1/2p; subunit of the ribosome-associated complex (RAC) that stimulates Ssb1/2p ATPase activity to facilitate interaction with nascent polypeptide chains emerging from the ribosome exit tunnel; regulates translation upon inhibition of TORC1; contains a DnaJ domain; human gene DNAJC2 partially complements the yeast zuo1 null mutant 1 2 3 4 5 6 7 8 9 10
- Name Description
- ZUOtin 1
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
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| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
2 entries for 2 complementsIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|---|---|---|---|---|---|
| Homo sapiens | HGNC:13192 | Other | other complements yeast | Truncation mutant lacking both SANT domains and residues of Helices II-IV of 4HB (Mpp11[1-361]) was nearly as effective at rescue as full-length protein. Cells expressing truncation variant Mpp11[1-345], which completely lacks Helix I sequences, grew as poorly as zuo1-Δ cells carrying only an empty plasmid. Isoform 2, a human splicing variant that lacks most Helix II-IV sequences, substantially rescues paromomycin sensitivity of yeast zuo1-Δ. These results are consistent with the positive charge of Helix I being important for ribosome association of human Mpp11, as for yeast Zuo1p. | SGD | Shrestha OK, et al. (2019) PMID:31091298 |
| Homo sapiens | HGNC:13192 | S288C | other complements yeast | This paper shows that human Mpp11 (ENSP00000249270) partially complements a yeast zuo1 null mutant. | P-POD | Hundley HA, et al. (2005) PMID:15802566 |
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
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| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
25 entries for 10 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| External ID | Source |
|---|---|
| orf19.2709 | CGD |
| 4720 | DIP |
| Z73070 | GenBank/EMBL/DDBJ |
| X63612 | GenBank/EMBL/DDBJ |
| AY692823 | GenBank/EMBL/DDBJ |
| 6321724 | GenBank/EMBL/DDBJ |
| CAA97317.1 | GenBank/EMBL/DDBJ |
| CAA45156.1 | GenBank/EMBL/DDBJ |
| AAT92842.1 | GenBank/EMBL/DDBJ |
| 418611 | GenBank/EMBL/DDBJ |
Resources
Homologs
AGD | AnalogYeast | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi