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LSB1 / YGR136W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

Feature Type
ORF , Verified
Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication 1 2 3 4
PIN3 4