PAC10 / YGR078C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutants show slow vegetative growth and fermentation, increased growth on palmitoleic and oleic acids; null mutants show increased cell size, abnormal budding, decreased competitive fitness, decreased osmotic stress resistance, abnormal vacuolar morphology, are impaired in endocytosis and actin polymerization, and sensitive to cold, ethanol, caffeine, heavy metals cadmium and arsenic, phosphatidylinositol 3-kinase inhibitor wortmannin, TOR inhibitor rapamycin, actin polymerization inhibitor latrunculin B, DNA synthesis inhibitor hydroxyurea, microtubule-destabilizing agent benomyl, fluorescent stain Calcofluor White, and various antimicrobials; homozygous diploid nulls are enhanced in respiration and oxidative stress resistance, and show increased mitotic recombination and chromosome loss

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources