Sequence Help

PMR1 / YGL167C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

SSC1 1 , BSD1 18 , LDB1 19
Protein Product
Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1
Feature Type
ORF , Verified
High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant 2 3 4 5 6 7 8
EC Number