MPS2 / YGL075C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene; conditional mutant has abnormal spindle morphology with disorganized microtubule arrays, a dysfunctional monopolar spindle with a second, defective SPB, arresting as large-budded cells in G2 phase, and becoming polyploid due to chromosome missegregation; overexpression results in accumulation of cells with medium to large buds in G2 phase, and inviability; heterozygous diploid null is haploinsufficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources