Sequence Help

AFT1 / YGL071W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

RCS1 9
Protein Product
DNA-binding transcription factor AFT1
Feature Type
ORF , Verified
Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress 2 3 4 5 6 7 8
AFT2 6