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ALG2 / YGL065C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Protein Product
GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
Feature Type
ORF , Verified
Description
Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in N-linked glycosylation pathway; mutants exhibit temperature-sensitive growth and abnormal accumulation of lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; mutations of human ALG2 cause congenital myasthenic syndrome; human ALG2 complements temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement 1 2 3 4 5 7
EC Number
2.4.1.132, 2.4.1.257

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