Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
18 entries for 13 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| auxotrophy | homozygous diploid, systematic mutation set | null Allele: sip1-Δ | S288C | myo-inositol | Villa-García MJ, et al. (2011) PMID:21136082 | |
| chemical compound accumulation: abnormal | systematic mutation set | null Allele: sip1-Δ | S288C | alpha-amino acid | Details: Significantly altered free amino acid profile (X^2- test p < 0.01) | Mülleder M, et al. (2016) PMID:27693354 |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: sip1-Δ | S288C | copper cation | Yu D, et al. (2012) PMID:23151179 | |
| competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: sip1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.008 | Breslow DK, et al. (2008) PMID:18622397 | |
| desiccation resistance: decreased | classical genetics | null Allele: sip1-Δ | S288C | Treatment: mutants grown to post-diauxic phase and then subject to desiccation Details: moderately affected with 35-60% survival after desiccation | Ratnakumar S, et al. (2011) PMID:20963216 | |
| fermentative metabolism: decreased | classical genetics | overexpression | Other | Meng L, et al. (2020) PMID:32571355 | ||
| filamentous growth: decreased | systematic mutation set | null Allele: sip1-Δ | Sigma1278b | Jin R, et al. (2008) PMID:17989363 | ||
| replicative lifespan: decreased | classical genetics | null Allele: sip1-Δ | S288C | Details: mean lifespan was reduced to 82% that of the wild type | Ashrafi K, et al. (2000) PMID:10921902 | |
| resistance to chemicals: decreased | homozygous diploid, systematic mutation set | null Allele: sip1-Δ | S288C | 460 uM dieldrin | Gaytán BD, et al. (2013) PMID:23358190 | |
| resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: sip1-Δ | S288C | 3 μg/mL doxorubicin | Lum PY, et al. (2004) PMID:14718172 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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