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VPS74 / YDR372C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

API1 8 , MNN3 9 10
Feature Type
ORF , Verified
Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; contributes to telomere function; ortholog of human GOLPH3/GPP34/GMx33 2 3 4 5 6 7