HRQ1 / YDR291W Overview


Standard Name
HRQ1 1
Systematic Name
YDR291W
SGD ID
SGD:S000002699
Feature Type
ORF , Verified
Description
3'-5' DNA helicase of conserved RecQ family; involved in Pso2p-mediated inter-strand crosslink repair; helicase activity impacted by DNA sequence and secondary structures; acts with Rad4p in nucleotide-excision repair; acts with Pif1p to inhibit telomerase, maintain telomere length; inhibits telomere addition to DNA double-strand breaks; does not have ssDNA annealing or strand exchange activities found in homologs; homolog of human RecQ4 implicated in Rothmund-Thomson syndrome (RTS) 1 2 3 4 5 6 7
Name Description
Homologous to RecQ protein 1
Comparative Info
Integrated model organism details available at the Alliance of Genome Resources website
Sequence Details

Sequence

The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.


Protein Details

Protein

Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.


Length (a.a.)
1077
Mol. Weight (Da)
123536.9
Isoelectric Point
6.65
Median Abundance (molecules/cell)
727 +/- 438
Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.


Summary
3'-5' DNA helicase activity involved in DNA duplex unwinding and DNA strand renaturation; has role in nucleotide-excision repair, interstrand cross-link repair, and positive regulation of nuclease activity

View computational annotations

Molecular Function

Manually Curated

Biological Process

Manually Curated

Cellular Component

High-Throughput
Phenotype Details

Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.


Disease Details

Disease

Disease Annotations consist of three mandatory components: a gene product, a term from the Disease Ontology (DO) controlled vocabulary and an evidence code. SGD provides manually curated DO Annotations derived from the literature. Click "Disease Details" to view all Disease information and evidence for this locus as well as diseases it shares with other genes.


Summary
Yeast HRQ1 is homologous to human RECQL4, and has been used to study Rothmund-Thomson, Baller-Gerold, and rapadilino syndromes
Interaction Details

Interaction

Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.


178 total interactions for 164 unique genes

Physical Interactions

  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 4
  • Co-fractionation: 1
  • Two-hybrid: 1

Genetic Interactions

  • Negative Genetic: 119
  • Phenotypic Enhancement: 2
  • Positive Genetic: 34
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1
Regulation Details

Regulation

The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.


No regulation data available.

Expression Details

Expression

Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.


Literature Details

Literature

All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.


Primary
15
Additional
4
Reviews
1

Resources