Sequence Help

SIR4 / YDR227W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

ASD1 , STE9 , UTH2
Protein Product
chromatin-silencing protein SIR4
Feature Type
ORF , Verified
SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some SIR4 alleles prolong lifespan; required for Ku-mediated telomerase recruitment, telomere lengthening, and telomere hypercluster formation in quiescent yeast cells 2 3 4 5 6