Phenotype Help

YDR199W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

9 entries for 8 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: ydr199w-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: ydr199w-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.997
Breslow DK, et al. (2008) PMID:18622397
metal resistance: increased
systematic mutation set null
Allele: ydr199w-Δ
S288C lithium(1+)Treatment: lithium chloride, 100 mM
Details: null mutants harboring growth above 150% at 100 mM LiCl were classified as being highly resistant; screen consisted of a 4 step approach including qualitative assessment on Li-agar plates, liquid microplate assessment, tertiary screening in liquid and a quaternary screen using Li2SO4, followed by classification based on the degree of sensitivity
Fierling N, et al. (2024) PMID:38142127
resistance to chemicals: decreased
competitive growth

fitness profiling of the non-essential deletion collection after 18 generations

null
Allele: ydr199w-Δ
S288C20 ug/ml cordycepinDetails: sensitivity increased two-fold or greater
Holbein S, et al. (2009) PMID:19324962
resistance to chemicals: decreased
systematic mutation setnull
Allele: ydr199w-Δ
S288C CG-1521Gaupel AC, et al. (2014) PMID:24968945
resistance to chemicals: increased
large-scale survey

variomic library screening of ~10,000 alleles for each gene

unspecifiedS288C20 ng/ml sirolimusDetails: sirolimus is rapamycin
Huang Z, et al. (2013) PMID:23416056
toxin resistance: decreased
systematic mutation set null
Allele: ydr199w-Δ
S288CTreatment: Aβ42
Details: decreased resistance to the toxicity of Aβ42, a 42 AA aggregate prone proteolytic product of the human amyloid precursor protein (APP)
Chen X, et al. (2020) PMID:32054832
utilization of nitrogen source: decreased rate
systematic mutation set

prototrophic version of yeast deletion collection

null
Allele: ydr199w-Δ
S288C ammoniumVanderSluis B, et al. (2014) PMID:24721214
viable
systematic mutation setnull
Allele: ydr199w-Δ
S288CGiaever G, et al. (2002) PMID:12140549
Showing 1 to 9 of 9 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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