Sequence Help

HST4 / YDR191W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

Protein Product
NAD-dependent histone deacetylase HST4
Feature Type
ORF , Verified
NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3 1 2 3 4 6
EC Number