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HST4 / YDR191W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Protein Product
NAD-dependent histone deacetylase HST4
Feature Type
ORF , Verified
Description
NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3 1 2 3 4
EC Number
2.3.1.286

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