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SCC2 / YDR180W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

Protein Product
cohesin-loading factor complex subunit SCC2
Feature Type
ORF , Verified
Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2; conserved role in NHEJ 1 2 3 4 5 6 7 8