Phenotype Help

HOM2 / YDR158W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

42 entries for 14 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
acid pH resistance: decreased
systematic mutation setnull
Allele: hom2-Δ
S288C0.1-0.4% boric acidSchmidt M, et al. (2012) PMID:22902726
auxotrophy
classical geneticsunspecifiedOther20 μg/ml methionine, 75-250 μg/ml threonineRobichon-Szulmajster H, et al. (1966) PMID:4380684
auxotrophy
classical geneticsunspecifiedOther75-250 μg/ml homoserineRobichon-Szulmajster H, et al. (1966) PMID:4380684
chemical compound accumulation: decreased
systematic mutation setnull
Allele: hom2-Δ
S288C hydrogen sulfideMedia: cysteine supplementation, 500 mg/L
Winter G, et al. (2014) PMID:25517415
chemical compound accumulation: increased
heterozygous diploid overexpressionS288C reactive oxygen speciesTutaj H, et al. (2019) PMID:30244280
chemical compound excretion: increased
classical genetics null
Allele: hom2-Δ
S288C hydrogen sulfideLinderholm AL, et al. (2008) PMID:18192430
chromosome/plasmid maintenance: decreased
heterozygous diploid, systematic mutation set overexpressionS288CDetails: mean frequency of loss of heterozygosity (LOH) at the CAN1 locus increased at least 2-fold; frequently accompanied by LOH at the MET6 locus indicating loss of the entire chr V
Tutaj H, et al. (2019) PMID:30244280
competitive fitness: decreased
systematic mutation set

fitness profiling after 15 generations

null
Allele: hom2-Δ
S288CMedia: synthetic medium, minimal +his/leu/ura medium
Giaever G, et al. (2002) PMID:12140549
competitive fitness: decreased
systematic mutation set

fitness profiling after 5 generations

null
Allele: hom2-Δ
S288CMedia: synthetic medium, minimal +his/leu/ura medium
Giaever G, et al. (2002) PMID:12140549
competitive fitness: decreased
systematic mutation set

fitness profiling after 5 generations

null
Allele: hom2-Δ
S288CMedia: synthetic medium, synthetic complete - thr medium
Giaever G, et al. (2002) PMID:12140549
Showing 1 to 10 of 42 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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