Phenotype Help

FOB1 / YDR110W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant exhibits lengthened replicative lifespan, increased resistance to MMS, and reduced Hot1p-mediated mitotic recombination; in large-scale studies, null mutant displays increased rDNA recombination during meiosis but decreased rDNA recombination during mitosis; null mutant shows reduced starvation resistance and competitive fitness

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

43 entries for 18 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chromosome/plasmid maintenance: decreased
systematic mutation setoverexpressionOtherAssay: a-like faker (ALF) assay
Details: dosage chromosome instability (dCIN) involving chromosome loss, rearrangement and/or gene conversion events
Duffy S, et al. (2016) PMID:27551064
chromosome/plasmid maintenance: decreased
heterozygous diploidnull
Allele: fob1-Δ
OtherDetails: >2-fold increase in the rate of chromosome loss, indicative of chromosome instability (CIN)
Strome ED, et al. (2008) PMID:18245329
chromosome/plasmid maintenance: decreased
classical genetics null
Allele: fob1-Δ
S288CDetails: reduction in rDNA copy number during long-term evolution experiments, with increased accumulation of extrachromosomal rDNA circles (ERCs)
Murai T, et al. (2024) PMID:38384843
chronological lifespan: decreased
competitive growth

competitive survival of mixed stationary phase co-cultures

null
Allele: fob1-Δ
S288CGaray E, et al. (2014) PMID:24586198
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: fob1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.981
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
competitive growth overexpressionS288CDetails: decreased abundance within the barFLEX overexpression collection arrayed after 20 generations of pooled growth
Douglas AC, et al. (2012) PMID:23050238
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: fob1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0036
Pir P, et al. (2012) PMID:22244311
haploinsufficient
heterozygous diploid, competitive growthnull
Allele: fob1-Δ
S288CTreatment: conditions that mimic Phase I of a batch fermentation, equivalent to ~14 hours after inoculation of a batch fermentation
Novo M, et al. (2013) PMID:24040173
meiotic recombination: increased
homozygous diploidnull
Allele: fob1-Δ
OtherDetails: increased meiotic rDNA recombination
Casper AM, et al. (2008) PMID:18584028
mitotic recombination: decreased
homozygous diploidnull
Allele: fob1-Δ
OtherDetails: decreased mitotic rDNA recombination
Casper AM, et al. (2008) PMID:18584028
Showing 1 to 10 of 43 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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