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STE5 / YDR103W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

HMD3 36 , NUL3 37
Feature Type
ORF , Verified
Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation 2 3 4 5 6 7 8 9 10