Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
12 entries for 11 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| chromosome/plasmid maintenance: decreased | heterozygous diploid | null Allele: rtr2-Δ | Other | Details: >2-fold increase in the rate of chromosome loss, indicative of chromosome instability (CIN) | Strome ED, et al. (2008) PMID:18245329 | |
| colony sectoring: increased | heterozygous diploid, systematic mutation set | null Allele: rtr2-Δ | S288C | Assay: quantitative chromosome transmission fidelity (qCTF) assay Details: >1.5 fold increase in mini-chromosome loss relative to wt, indicative of chromosome instability (CIN) | Zhu J, et al. (2015) PMID:25823586 | |
| competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: rtr2-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.001 | Breslow DK, et al. (2008) PMID:18622397 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: rtr2-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0047 | Pir P, et al. (2012) PMID:22244311 | |
| protein/peptide accumulation: increased Reporter: Rnr3p | systematic mutation set | null Allele: ydr066c-Δ | S288C | 0.03% methyl methanesulfonate | Hendry JA, et al. (2015) PMID:25721128 | |
| protein/peptide distribution: abnormal Reporter: Rpb1-GFP | classical genetics | null Allele: rtr2-Δ | S288C | Details: increase in the nuclear:cytoplasmic ratio of Rpb1p, suggestive of a negative regulatory role in RNAPII import through phosphorylation of the CTD | Minaker SW, et al. (2021) PMID:34180355 | |
| resistance to chemicals: decreased | heterozygous diploid | null Allele: rtr2-Δ | Other | 10 ug/ml benomyl | Strome ED, et al. (2008) PMID:18245329 | |
| resistance to chemicals: decreased | systematic mutation set | null Allele: rtr2-Δ | S288C | CG-1521 | Gaupel AC, et al. (2014) PMID:24968945 | |
| resistance to chemicals: increased | large-scale survey variomic library screening of ~10,000 alleles for each gene | unspecified | S288C | 100 ng/ml cycloheximide | Huang Z, et al. (2013) PMID:23416056 | |
| utilization of nitrogen source: decreased rate | systematic mutation set prototrophic version of yeast deletion collection | null Allele: rtr2-Δ | S288C | glutamate(1-) | VanderSluis B, et al. (2014) PMID:24721214 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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