Phenotype Help

YRB1 / YDR002W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

27 entries for 13 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
cell cycle progression: abnormal
large-scale surveyoverexpressionW303Details: greater than 10% shift in cells containing a 1C DNA content, indicative of a G1 phase arrest or delay
Stevenson LF, et al. (2001) PMID:11274415
colony sectoring: increased
homozygous diploid, large-scale surveyoverexpressionS288CDetails: sectoring due to loss of a chromosome fragment, an indicator of altered chromosome stability
Ouspenski II, et al. (1999) PMID:10454593
colony sectoring: increased
homozygous diploidoverexpressionS288CDetails: increased frequency of chromosome loss and non-disjunction; 25- and 50-fold respectively
Ouspenski II, et al. (1999) PMID:10454593
competitive fitness: decreased
competitive growth

fitness profiling of essential genes using hypomorphic DAmP alleles

reduction of functionS288CMedia: minimal medium
Details: Relative fitness score: 0.950
Breslow DK, et al. (2008) PMID:18622397
haploproficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: yrb1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: 0.0094
Pir P, et al. (2012) PMID:22244311
inviable
systematic mutation setnull
Allele: yrb1-Δ
S288CGiaever G, et al. (2002) PMID:12140549
inviable
classical geneticsnull
Allele: yrb1-Δ
OtherOuspenski II, et al. (1995) PMID:7836422
mitotic recombination: increased
classical geneticsoverexpressionS288CDetails: elevated mitotic recombination frequency; 40-fold
Ouspenski II, et al. (1999) PMID:10454593
nuclear export: abnormal
classical geneticsconditional
Allele: yrb1-1

E182D, F187S

OtherTemperature: elevated temperature, 37 °C
Details: poly(A)+ RNA accumulates in the nucleus
Schlenstedt G, et al. (1995) PMID:7489726
nuclear import: decreased
classical geneticsconditional
Allele: yrb1-1

E182D, F187S

OtherTemperature: elevated temperature, 37 °C
Schlenstedt G, et al. (1995) PMID:7489726
Showing 1 to 10 of 27 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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