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HEM3 / YDL205C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

OLE2 2 12
Protein Product
hydroxymethylbilane synthase
Feature Type
ORF , Verified
Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid 1 2 3
EC Number