Sequence Help

SIR2 / YDL042C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

MAR1 27
Protein Product
NAD-dependent histone deacetylase SIR2
Feature Type
ORF , Verified
Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy 1 2 3 4 5 6 7
EC Number