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MPS1 / YDL028C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

RPK1 , PAC8 23
Protein Product
serine/threonine/tyrosine protein kinase MPS1
Feature Type
ORF , Verified
Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body (SPB) duplication and spindle checkpoint function; contributes to bi-orientation by promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); similar to human Mps1p 2 3 4 5 6 7 8 9 10
EC Number