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CDC7 / YDL017W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

LSD6 , SAS1 41
Protein Product
serine/threonine protein kinase CDC7
Feature Type
ORF , Verified
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase); required for origin firing and replication initiation; phosphorylates MCM subunits and Cdc45 to drive assembly of the pre-IC and the CMG helicase; maintains Cse4p at kinetochores through phosphorylation to regulate chromosome segregation, regulates pre-meiotic replication, meiotic DSB formation, monopolar attachment of homologs during MI through monopolin recruitment and middle meiotic gene expression; HsCDC7 and DBF4 complement 2 3 4 5 7 8 9 10 11 12 13 14 15 16 17 18
EC Number