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CDC7 / YDL017W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
LSD6 , SAS1 40
Protein Product
serine/threonine protein kinase CDC7
Feature Type
ORF , Verified
Description
Ser/Thr kinase and catalytic subunit of DDK (Dbf4-dependent kinase); required for origin firing and replication initiation; phosphorylates MCM subunits and Cdc45p to drive assembly of the pre-IC and the replicative CMG helicase (Cdc45-MCM-GINS); regulates pre-meiotic DNA replication, meiotic DSB formation, monopolar attachment of homologs during MI by recruiting monopolin to kinetochores, and regulation of middle meiotic genes including NDT80; complemented by co-expression of human CDC7 and DBF4 2 3 4 5 7 8 9 10 11 12 13 14 15 16 17
EC Number
2.7.11.1

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