Phenotype Help

RSC8 / YFR037C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

31 entries for 14 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
cell cycle progression in G1 phase: arrested
classical geneticsrepressibleW303Details: irreversible lethality associated with the arrest
Campsteijn C, et al. (2007) PMID:17542652
cell cycle progression through the G2/M phase transition: arrested
classical geneticsrepressibleW303Details: irreversible lethality associated with the arrest
Campsteijn C, et al. (2007) PMID:17542652
colony sectoring: increased
large-scale surveyconditional
Allele: rsc8-ts21
S288CAssay: chromosome transmission fidelity (CTF) assay
Temperature: semi-permissive temperature
Details: indicative of chromosome instability (CIN); metascore strong (single hit)
Stirling PC, et al. (2011) PMID:21552543
competitive fitness: increased
competitive growth

fitness profiling of essential genes using hypomorphic DAmP alleles

reduction of functionS288CMedia: minimal medium
Details: Relative fitness score: 1.014
Breslow DK, et al. (2008) PMID:18622397
haploproficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: rsc8-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: 0.0029
Pir P, et al. (2012) PMID:22244311
innate thermotolerance: increased
heterozygous diploid, systematic mutation setnull
Allele: rsc8-Δ
S288CPhase: exponential phase
Treatment: heat shock, 50 °C
Details: resistance scale of 1 (least) to 4 (most) resistant: 1
Jarolim S, et al. (2013) PMID:24142923
inviable
classical geneticsnull
Allele: rsc8-Δ
S288CTreich I and Carlson M (1997) PMID:9121424
inviable
systematic mutation setnull
Allele: rsc8-Δ
S288CGiaever G, et al. (2002) PMID:12140549
metal resistance: decreased
systematic mutation set overexpressionS288C2 mM copper(II) sulfateDetails: exacerbates toxicity
Chakrabortee S, et al. (2016) PMID:27693355
protein/peptide distribution: abnormal
Reporter: Ace2-YFP
systematic mutation set conditional
Allele: rsc8-ts16
OtherTemperature: elevated temperature, 37 °C
Details: class I mutant; partial phenotype with some displaying asymmetric localization of Ace2p in telophase daughter cell nuclei like wt cells and some showing symmetric localization in both mother and daughter cells
Herrero E, et al. (2020) PMID:32878900
Showing 1 to 10 of 31 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


Resources