Phenotype Help

FRS2 / YFL022C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

7 entries for 7 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
cell cycle progression: abnormal
systematic mutation setoverexpressionS288CDetails: accumulation of cells with a 2C DNA content and an increased percentage of large-budded cells indicative of a G2 or M phase delay or arrest
Niu W, et al. (2008) PMID:18617996
colony sectoring: increased
systematic mutation set

hypomorphic DAmP allele in which an insertion in the 3'UTR reduces mRNA stability

reduction of functionS288CAssay: chromosome transmission fidelity (CTF) assay
Details: indicative of chromosome instability (CIN); metascore weak (single hit)
Stirling PC, et al. (2011) PMID:21552543
competitive fitness: decreased
competitive growth

fitness profiling of essential genes using hypomorphic DAmP alleles

reduction of functionS288CMedia: minimal medium
Details: Relative fitness score: 0.633
Breslow DK, et al. (2008) PMID:18622397
heat sensitivity: increased
large-scale surveyconditional
Allele: frs2-ts
S288CTemperature: elevated temperature, 37 °C
Details: no growth
Ben-Aroya S, et al. (2008) PMID:18439903
inviable
systematic mutation setnull
Allele: frs2-Δ
S288CGiaever G, et al. (2002) PMID:12140549
resistance to chemicals: decreased
classical geneticsreduction of function
Allele: frs2-(frs1-1)

defective post-transfer editing activity

Other2 mM paraquatMoghal A, et al. (2016) PMID:27226603
vegetative growth: decreased
classical geneticsreduction of function
Allele: frs2-(frs1-1)

defective post-transfer editing activity

OtherMoghal A, et al. (2016) PMID:27226603
Showing 1 to 7 of 7 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


Resources