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SRL3 / YKR091W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

WHI7 6
Protein Product
DNA-binding protein SRL3
Feature Type
ORF , Verified
Repressor of transcription at Start; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; inhibitor of Start that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger Start; Srl3p is unstable and degraded by SCF-Grr1 after Cdc28p-dependent phosphorylation; contains a GTB (G1/S transcription factor binding) motif; binds SBF-regulated promoters in HU-treated cells; Cdc28p substrate 2 3 4 5 6 7 8