Phenotype Help

SPC34 / YKR037C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

15 entries for 12 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
autophagy: decreased
large-scale survey repressibleS288CMedia: nitrogen starvation
Details: impaired nitrogen starvation-induced autophagy via reduced vacuolar localization of GFP-Atg8 and defective cleavage of GFP-Atg8; used a conditional degradation library with a C-terminal auxin-inducible degron (miniAID); also defective in glucose starvation and DNA damage-induced autophagy (0.04% MMS)
Yi C, et al. (2025) PMID:39988731
chromosome/plasmid maintenance: abnormal
systematic mutation set

hypomorphic DAmP allele in which an insertion in the 3'UTR reduces mRNA stability

reduction of functionS288CAssay: gross-chromosomal rearrangement (GCR) assay
Details: indicative of chromosome instability (CIN); metascore weak (multiple hit)
Stirling PC, et al. (2011) PMID:21552543
colony sectoring: increased
systematic mutation set

hypomorphic DAmP allele in which an insertion in the 3'UTR reduces mRNA stability

reduction of functionS288CAssay: chromosome transmission fidelity (CTF) assay
Details: indicative of chromosome instability (CIN); metascore weak (multiple hit)
Stirling PC, et al. (2011) PMID:21552543
competitive fitness: decreased
competitive growth

fitness profiling of essential genes using hypomorphic DAmP alleles

reduction of functionS288CMedia: minimal medium
Details: Relative fitness score: 0.963
Breslow DK, et al. (2008) PMID:18622397
filamentous growth: increased
systematic mutation setoverexpressionSigma1278bJin R, et al. (2008) PMID:17989363
haploinsufficient
heterozygous diploid, systematic mutation set null
Allele: spc34-Δ
S288COhnuki S and Ohya Y (2018) PMID:29768403
inviable
systematic mutation setnull
Allele: spc34-Δ
S288CGiaever G, et al. (2002) PMID:12140549
mitochondrial morphology: abnormal
systematic mutation setrepressibleS288C10 ug/ml doxycyclineDetails: Tet-regulated essential ORF strain collection; doxycycline represses expression
Altmann K and Westermann B (2005) PMID:16135527
protein/peptide distribution: abnormal
Reporter: Ace2-YFP
systematic mutation set conditional
Allele: spc34 41-1
OtherTemperature: elevated temperature, 37 °C
Details: class I mutant; partial phenotype with some displaying asymmetric localization of Ace2p in telophase daughter cell nuclei like wt cells and some showing symmetric localization in both mother and daughter cells
Herrero E, et al. (2020) PMID:32878900
resistance to chemicals: decreased
heterozygous diploid, systematic mutation setnull
Allele: spc34-Δ
S288Cepothilon B analog epothiloneHoepfner D, et al. (2014) PMID:24360837
Showing 1 to 10 of 15 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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