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GCN3 / YKR026C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

AAS2 16
Protein Product
translation initiation factor eIF2B subunit alpha
Feature Type
ORF , Verified
Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity regulated by phosphorylated eIF2; positive regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog EIF2B1 can complement yeast null mutant 2 4 5 6