Phenotype Help

PAP1 / YKR002W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

33 entries for 20 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
cell cycle progression: abnormal
large-scale surveyoverexpressionW303Details: greater than 5% shift in cells containing a 2C DNA content, indicative of a G2 or M phase arrest or delay
Stevenson LF, et al. (2001) PMID:11274415
chemical compound accumulation: increased
classical geneticsconditional
Allele: pap1-2
Other ATPTemperature: permissive temperature, 25 °C
Details: significant increase in cellular ATP content; similar results with pap1-5
Holbein S, et al. (2009) PMID:19324962
competitive fitness: increased
competitive growth

fitness profiling of essential genes using hypomorphic DAmP alleles

reduction of functionS288CMedia: minimal medium
Details: Relative fitness score: 1.010
Breslow DK, et al. (2008) PMID:18622397
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: pap1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.008
Pir P, et al. (2012) PMID:22244311
haploinsufficient
heterozygous diploid, systematic mutation set null
Allele: pap1-Δ
S288COhnuki S and Ohya Y (2018) PMID:29768403
heat sensitivity: increased
classical geneticsconditional
Allele: pap1-1
S288CTemperature: elevated temperature, 30 °C
Burkard KT and Butler JS (2000) PMID:10611239
heat sensitivity: increased
classical geneticsconditional
Allele: pap1-2
OtherTemperature: semi-permissive temperature, 33 °C
Holbein S, et al. (2009) PMID:19324962
invasive growth: increased
homozygous diploid, systematic mutation setoverexpressionSigma1278bMedia: nitrogen-sufficient medium
Details: agar invasion score: 0.99; enhanced pseudohyphal growth, based on elevated invasiveness
Shively CA, et al. (2013) PMID:23410832
inviable
systematic mutation setnull
Allele: pap1-Δ
S288CGiaever G, et al. (2002) PMID:12140549
inviable
systematic mutation setoverexpressionS288CSopko R, et al. (2006) PMID:16455487
Showing 1 to 10 of 33 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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