Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
26 entries for 14 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| autophagy: decreased | large-scale survey | repressible | S288C | Media: nitrogen starvation Details: impaired nitrogen starvation-induced autophagy via reduced vacuolar localization of GFP-Atg8 and defective cleavage of GFP-Atg8; used a conditional degradation library with an N-terminal auxin-inducible degron (miniAID); also defective in glucose starvation and DNA damage-induced autophagy (0.04% MMS) | Zhang Y, et al. (2025) PMID:39988731 | |
| endomembrane system morphology: abnormal | classical genetics | repressible | W303 | Details: accumulation of cytoplasmically-dispersed 50 nm diameter transport vesicles | McNew JA, et al. (1997) PMID:9211930 | |
| endoplasmic reticulum morphology: abnormal | classical genetics | repressible | W303 | Details: accumulation of ER membranes continuous with the nuclear envelope | McNew JA, et al. (1997) PMID:9211930 | |
| growth in exponential phase: decreased rate | classical genetics | conditional Allele: ykt6-1 S35G, L125Q, D139G, S182R, M185T | SEY6210 | Temperature: semi-permissive temperature, 30 °C Details: doubling time 2.7 hrs compared to 1.7 hrs for WT | Tsui MM and Banfield DK (2000) PMID:10591633 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: ykt6-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0047 | Pir P, et al. (2012) PMID:22244311 | |
| heat sensitivity: increased | classical genetics | conditional Allele: ykt6-1 S35G, L125Q, D139G, S182R, M185T | SEY6210 | Temperature: elevated temperature, 37 °C | Tsui MM and Banfield DK (2000) PMID:10591633 | |
| heat sensitivity: increased | large-scale survey | conditional Allele: ykt6-ts | S288C | Temperature: elevated temperature, 37 °C Details: no growth | Ben-Aroya S, et al. (2008) PMID:18439903 | |
| inviable | systematic mutation set | null Allele: ykt6-Δ | S288C | Giaever G, et al. (2002) PMID:12140549 | ||
| inviable | classical genetics | null Allele: ykt6-Δ | W303 | McNew JA, et al. (1997) PMID:9211930 | ||
| inviable | classical genetics | reduction of function Allele: ykt6-S182D,S183D change to phosphomimetic Asp | S288C | Gao J, et al. (2020) PMID:33025734 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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