AAT1 / YKL106W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene; null mutant has a reduced respiratory growth rate and decreased competitive fitness on non-fermentable carbon sources; null has reduced groth on minimal medium and a reduced ability to use proline as a nitrogen source; null mutant has a reduction in caloric restriction-mediated lifespan extension, while overexpression enhances both chronological and replicative lifespan; overexpression increases silencing at the rDNA locus; null mutant has enhanced biofilm formation; heterozygous null mutant is haploinsufficient

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources