Sequence Help
CSE4 / YKL049C Sequence
Sequences and genome annotation information for Reference Strain S288C and a select set of
Alternative References.
- Aliases
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CSL2
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- Protein Product
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centromeric DNA-binding histone H3-like protein CSE4
- Feature Type
- ORF
, Verified
- Description
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Centromeric histone H3-like protein; associates with promoters, accessible chromatin, and RNAPII-bound regions; Cse4p associates with centromeres, promoting kinetochore assembly and Sgo1p association with centromeric chromatin; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting bi-orientation; phosphorylation by Cdc7p maintains Cse4p at kinetochores and promotes faithful chromosome segregation; regulated by multiple E3 ligases; complements human homolog CENPA mutations
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