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CSE4 / YKL049C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

CSL2 12
Protein Product
centromeric DNA-binding histone H3-like protein CSE4
Feature Type
ORF , Verified
Centromeric histone H3-like protein; associates with promoters, accessible chromatin, and RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for kinetochore function; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting bi-orientation; increases association of Sgo1p with centromeric chromatin; proteolysis regulated by multiple E3 ligases, resulting in faithful chromosome segregation; CSE4 complements mutations in the human homolog CENPA 1 2 3 4 5 6 7 8 9 10 11