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CSE4 / YKL049C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

CSL2 13
Protein Product
centromeric DNA-binding histone H3-like protein CSE4
Feature Type
ORF , Verified
Centromeric histone H3-like protein; associates with promoters, accessible chromatin, and RNAPII-bound regions; Cse4p associates with centromeres, promoting kinetochore assembly and Sgo1p association with centromeric chromatin; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting bi-orientation; phosphorylation by Cdc7p maintains Cse4p at kinetochores and promotes faithful chromosome segregation; regulated by multiple E3 ligases; complements human homolog CENPA mutations 1 2 3 4 5 6 7 8 9 10 11 12