Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
14 entries for 11 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| cell shape: abnormal | classical genetics | overexpression | Sigma1278b | Media: galactose, 2 % Details: hyperpolarized growth; elongated cells with irregular morphologies that produce chains of filaments | Jamalzadeh S, et al. (2020) PMID:33335117 | |
| cold sensitivity: increased | classical genetics | conditional Allele: tfa1-Q273ochre C-terminal truncation, e.g. Q273ochre and others | Other | Temperature: reduced temperature, 15 °C | Kuldell NH and Buratowski S (1997) PMID:9271406 | |
| colony sectoring: increased | systematic mutation set hypomorphic DAmP allele in which an insertion in the 3'UTR reduces mRNA stability | reduction of function | S288C | Assay: chromosome transmission fidelity (CTF) assay Details: indicative of chromosome instability (CIN); metascore weak (single hit) | Stirling PC, et al. (2011) PMID:21552543 | |
| competitive fitness: increased | competitive growth fitness profiling of essential genes using hypomorphic DAmP alleles | reduction of function | S288C | Media: minimal medium Details: Relative fitness score: 1.002 | Breslow DK, et al. (2008) PMID:18622397 | |
| heat sensitivity: decreased | systematic mutation set | overexpression | S288C | Temperature: elevated temperature, 39 °C Details: abrogates toxicity | Chakrabortee S, et al. (2016) PMID:27693355 | |
| heat sensitivity: increased | classical genetics | conditional Allele: tfa1-C127R Zn-binding motif mutation, e.g. C127R and others | Other | Temperature: elevated temperature, 37 °C | Kuldell NH and Buratowski S (1997) PMID:9271406 | |
| invasive growth: increased | classical genetics | overexpression | Sigma1278b | Media: galactose, 2 % Details: hyper-invasive growth identified using the plate-washing assay | Jamalzadeh S, et al. (2020) PMID:33335117 | |
| inviable | systematic mutation set | null Allele: tfa1-Δ | S288C | Giaever G, et al. (2002) PMID:12140549 | ||
| inviable | classical genetics | null Allele: tfa1-Δ | Other | Feaver WJ, et al. (1994) PMID:7961670 | ||
| inviable | classical genetics | null Allele: tfa1-Δ | S288C | Wysocki R, et al. (1999) PMID:10095102 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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