Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
16 entries for 11 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: vth1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.02 | Breslow DK, et al. (2008) PMID:18622397 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: vth1-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0057 | Pir P, et al. (2012) PMID:22244311 | |
| heat sensitivity: decreased | systematic mutation set high throughput heat ramp cell death assay | null Allele: vth1-Δ | S288C | Temperature: elevated temperature Details: ramp temperature from ambient to 30 deg C immediately, hold 1 min at 30 deg C, ramp temperature from 30 deg C to 62 deg C over 20 min, return to ambient | Teng X, et al. (2011) PMID:21814286 | |
| mitotic recombination: decreased | systematic mutation set | null Allele: vth1-Δ | S288C | Details: spontaneous direct-repeat hypo-recombination identified using a high-throughput replica-pinning technique; recombination frequency of less than 33% compared to 56% for wt | Novarina D, et al. (2020) PMID:32265288 | |
| oxidative stress resistance: decreased | homozygous diploid, competitive growth | null Allele: vth1-Δ | S288C | 3 mM hydrogen peroxide | Brown JA, et al. (2006) PMID:16738548 | |
| resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: vth1-Δ | S288C | mercury dichloride | Hoepfner D, et al. (2014) PMID:24360837 | |
| resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: vth1-Δ | S288C | derivative myriocin | Hoepfner D, et al. (2014) PMID:24360837 | |
| resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: vth1-Δ | S288C | chondramide derivative | Hoepfner D, et al. (2014) PMID:24360837 | |
| resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: vth1-Δ | S288C | SDZ 90-215 | Hoepfner D, et al. (2014) PMID:24360837 | |
| silencing: decreased | systematic mutation set | null Allele: vth1-Δ | S288C | Details: decreased silencing at the silent mating type locus HMR based on expression of integrated URA3; confirmed using a Bioscreen mini-liquid culture assay | Liu Q, et al. (2020) PMID:32469861 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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