Sequence Help

SSM4 / YIL030C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

KIS3 14 , DOA10 2
Protein Product
E3 ubiquitin-protein ligase SSM4
Feature Type
ORF , Verified
Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity 2 3 4 5 6
EC Number