BRL1 / YHR036W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Essential gene in reference strain S288C; conditional mutant is heat and cold sensitive, and slow growing at permissive temperature; repressible mutant has a G1 delay; conditional mutant is sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents, accumulating ergosterol, sterol precursors and monounsaturated fatty acids at permissive temperatures; conditional mutant is defective in the nuclear export of poly(A)+ mRNA, and mislocalizes nuclear pore complex (NPC) cytoplasmic filament proteins; conditional mutant has a nuclear morphology defect with abnormal nuclear envelope, and an abnormal lipid particle arrangement with a circular pattern of droplets surrounding the nucleus; conditional mutant has a strong chromosomal instability phenotype; overexpression results in enhanced pseudohyphal and invasive growth

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

73 entries for 20 phenotypes

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

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