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RSP5 / YER125W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
MDP1 26 , MUT2 27 , NPI1 28 , UBY1 , SMM1 29
Protein Product
NEDD4 family E3 ubiquitin-protein ligase
Feature Type
ORF , Verified
Description
NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome 2 3 4 5 6 7 9 10 11 12 13 14 15 16 17 18
EC Number
2.3.2.26

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