Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
44 entries for 22 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| anaerobic growth: decreased | systematic mutation set | null Allele: vtc1-Δ | S288C | Treatment: anoxia Details: poor growth as indicated by measurements of colony size | Samanfar B, et al. (2013) PMID:23467670 | |
| cell cycle progression in G1 phase: increased duration | homozygous diploid, systematic mutation set | null Allele: vtc1-Δ | S288C | Details: percentage of G1 cells greater than two standard deviations (41.57%) above wild type when assayed by FACS | Hoose SA, et al. (2012) PMID:22438835 | |
| chemical compound accumulation: abnormal | systematic mutation set | null Allele: vtc1-Δ | S288C | polyphosphate | Freimoser FM, et al. (2006) PMID:17107617 | |
| chemical compound accumulation: absent | classical genetics | null Allele: vtc1-Δ | Other | polyphosphate | Treatment: polyphosphate overplus (phosphate starvation followed by high phosphate treatment) Details: lack detectable polyphosphate | Ogawa N, et al. (2000) PMID:11102525 |
| chemical compound accumulation: decreased | classical genetics | null Allele: vtc1-Δ | S288C | polyphosphate | Hothorn M, et al. (2009) PMID:19390046 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: vtc1-Δ | S288C | phosphorus(1+) | Yu D, et al. (2012) PMID:23151179 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: vtc1-Δ | S288C | magnesium cation | Yu D, et al. (2012) PMID:23151179 | |
| chemical compound accumulation: decreased | systematic mutation set | null Allele: vtc1-Δ | S288C | histidine | Mülleder M, et al. (2016) PMID:27693354 | |
| chemical compound accumulation: decreased | classical genetics | null Allele: vtc1-Δ | Other | polyphosphate | Details: significant reduction in cellular PolyP content | Liu W, et al. (2023) PMID:37066886 |
| chemical compound accumulation: decreased | classical genetics | reduction of function Allele: vtc1-K24E K24E; charge-reversing point mutation located on the cytoplasmic surface of the VTC channel | Other | polyphosphate | Details: significant reduction in cellular PolyP content | Liu W, et al. (2023) PMID:37066886 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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