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TPA1 / YER049W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Protein Product
oxidative DNA demethylase
Feature Type
ORF , Verified
Description
Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1 1 2 3 4 5 6

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