Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
19 entries for 12 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| competitive fitness: decreased | competitive growth fitness profiling of essential genes using hypomorphic DAmP alleles | reduction of function | S288C | Media: minimal medium Details: Relative fitness score: 0.901 | Breslow DK, et al. (2008) PMID:18622397 | |
| haploinsufficient | heterozygous diploid, competitive growth | null Allele: gcd11-Δ | S288C | Treatment: conditions that mimic Phase I of a batch fermentation, equivalent to ~14 hours after inoculation of a batch fermentation | Novo M, et al. (2013) PMID:24040173 | |
| heat sensitivity: increased | classical genetics | reduction of function Allele: gcd11-V281K | Other | Media: minimal synthetic dextrose (SD) Temperature: elevated temperature, 37 °C | Skopkova M, et al. (2017) PMID:28055140 | |
| innate thermotolerance: increased | heterozygous diploid, systematic mutation set | null Allele: gcd11-Δ | S288C | Phase: exponential phase Treatment: heat shock, 50 °C Details: resistance scale of 1 (least) to 4 (most) resistant: 1 | Jarolim S, et al. (2013) PMID:24142923 | |
| invasive growth: increased | homozygous diploid, systematic mutation set | overexpression | Sigma1278b | Media: nitrogen-sufficient medium Details: agar invasion score: 0.97; enhanced pseudohyphal growth, based on elevated invasiveness | Shively CA, et al. (2013) PMID:23410832 | |
| inviable | systematic mutation set | null Allele: gcd11-Δ | S288C | Giaever G, et al. (2002) PMID:12140549 | ||
| inviable | classical genetics | null Allele: gcd11-K250A all other amino acid substitutions at K250 lethal except K250R and K250M | S288C | Erickson FL and Hannig EM (1996) PMID:8947054 | ||
| resistance to chemicals: decreased | heterozygous diploid, systematic mutation set | null Allele: gcd11-Δ | S288C | geldanamycin | Hoepfner D, et al. (2014) PMID:24360837 | |
| resistance to chemicals: decreased | systematic mutation set | conditional Allele: gcd11-5001 | S288C | 10 ug/mL micafungin | Forster DT, et al. (2022) PMID:36192463 | |
| resistance to chemicals: increased | systematic mutation set | conditional Allele: gcd11-5001 | S288C | 2 ug/mL camptothecin | Forster DT, et al. (2022) PMID:36192463 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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