Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference. Experimental details, phenotype, modification, and multiple mutant information are included when available.
Source: All physical and genetic interaction annotations listed in SGD are curated by BioGRID.
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
|---|
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Interactor | Assay | Annotation | Action | Modification | Reference | |
|---|---|---|---|---|---|---|
Atg8 interactors upon 1 h of nitrogen starvation | ATG8 | Proximity Label-MS | high-throughput | Hit | No Modification | Filali-Mouncef Y, et al. (2024) PMID:38958087 |
Supplementary Table 1|bimolecular fluorescence complementation | CMR1 | PCA | high-throughput | Hit | No Modification | Gallina I, et al. (2015) PMID:25817432 |
| CUZ1 | Affinity Capture-MS | manually curated | Hit | No Modification | Sá-Moura B, et al. (2013) PMID:24121501 | |
| DBP10 | Affinity Capture-MS | high-throughput | Hit | No Modification | Cruz VE, et al. (2024) PMID:38632236 | |
A protein microarray was probed with the WW domain from ESS1 (YJR017C).|High Throughput: Each WW-domain was used as a probe for two separate protein microarrays. Only those in which four independent interactions were osbserved were considered high-confidence (i.e. significant signals found for proteins printed in duplicate on two separate microarrays). | ESS1 | Protein-peptide | high-throughput | Hit | No Modification | Hesselberth JR, et al. (2006) PMID:16606443 |
proteins interact with cytoplasmic domain of Msb2p on a protein microarray | MSB2 | Reconstituted Complex | high-throughput | Hit | No Modification | Prabhakar A, et al. (2019) PMID:31710471 |
High Throughput: The experiment involved high-throughput sequencing of the RNAs that co-precipitated with TAP-tagged Nab2 (Nab2-TAP). | NAB2 | Affinity Capture-RNA | high-throughput | Hit | No Modification | Batisse J, et al. (2009) PMID:19840948 |
| NPL6 | Affinity Capture-MS | high-throughput | Hit | No Modification | Krogan NJ, et al. (2006) PMID:16554755 | |
| NUP170 | Affinity Capture-MS | high-throughput | Hit | No Modification | Choudhry SK, et al. (2023) PMID:37358474 | |
32P incorporation on protein chip | PHO85 | Biochemical Activity | high-throughput | Hit | phosphorylated residue | Ptacek J, et al. (2005) PMID:16319894 |
This diagram displays physical (purple lines) and genetic (green lines) interactions between the given gene (yellow circle) and its interactors (gray circles) based on the number of experiments supporting each interaction (adjustable using the slider at the bottom). Interactions between the interactors for a given gene are also shown.
Click on a gene to go to its specific page within SGD; drag any of the gene objects around within the visualization for easier viewing; filter by interaction type (genetic or physical) using the radio buttons; click “Reset” to automatically redraw the diagram; filter the number of interactors displayed by adjusting the number of experiments supporting a gene's interaction with the given gene by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap | YeastRC Two-Hybrid